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KMID : 1094720220270010145
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Biotechnology and Bioprocess Engineering
2022 Volume.27 No. 1 p.145 ~ p.155
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Two-component Adsorption Characteristics of Paclitaxel and 10-deacetylpaclitaxel from Taxus chinensis onto Sylopute
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Kang Da-Yeon
Kim Jin-Hyun
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Abstract
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A batch experiment was conducted to investigate the effect of 10-deacetylpaclitaxel (10-DAP) on the adsorption characteristics of paclitaxel in a two-component adsorption of paclitaxel and 10-DAP by varying the concentration of 10-DAP (1,000?3,000 ppm) and adsorption temperature (298?318 K). The maximum adsorbed amount and adsorption rate constant of paclitaxel decreased by 10.1?21.3% and 5.5?28.6% at 298 K, 6.0?20.4% and 5.8?28.4% at 308 K, and 6.2?17.7% and 7.5?29.0% at 318 K, respectively, compared with the single-component adsorption of paclitaxel (control). These results show that the decrease rate was higher as the concentration of 10-DAP increased. In addition, as the concentration of 10-DAP increased, the adsorption rate constant decreased at all the adsorption temperatures, indicating that 10-DAP inhibited the adsorption of paclitaxel. The intraparticle diffusion rates decreased by 2.6?6.6% (10-DAP 1,000 ppm), 3.6?8.2% (10-DAP 2,000 ppm), and 8.0?10.0% (10-DAP 3,000 ppm) compared with the control. The thermodynamic study showed that the two-component adsorption was physical, endothermic, irreversible, and nonspontaneous.
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KEYWORD
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paclitaxel, 10-deacetylpaclitaxel, Sylopute, two-component adsorption, adsorption kinetics, thermodynamics
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